Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28984211 | 0.95 | HTR2C (0.50) | HTR2CHTR2AHTR2BEEDSRC | |
| SCHEMBL9411925 | 0.88 | HTR2C (0.57) | HTR2CHTR2AHTR2BEEDHTR1A | |
| SCHEMBL9618314 | 0.70 | HTR2A (0.45) | HTR2CHTR2AHTR2BHTR1ADRD3 | |
| SCHEMBL13983903 | 0.69 | HTR2C (0.66) | HTR2CHTR2AHTR2BHTR1ADRD3 | |
| SCHEMBL19511770 | 0.69 | SRC (0.46) | SRCPRKD1 | |
| SCHEMBL14181103 | 0.67 | FKBP5 (0.33) | HTR2CHTR2AHTR2B | |
| SCHEMBL21187691 | 0.67 | KIF11 (0.40) | SRCPRKD1 | |
| SCHEMBL30310107 | 0.67 | HTR2C (0.45) | HTR2CHTR2AHTR2BHTR1ADRD3 | |
| SCHEMBL30310105 | 0.67 | HTR2C (0.45) | HTR2CHTR2AHTR2BHTR1ADRD3 | |
| SCHEMBL29958302 | 0.66 | HTR2A (0.44) | HTR2CHTR2AHTR2BHTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599810-A | ADMINISTERING IN TREATMENT OF BENIGN PROSTATIC HYPERTROPHY, PERIPHERAL VASCULAR DISEASE AND CONGESTIVE HEART FAILURE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0684949-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0684949-A4 | CHEMICAL COMPOUNDS. | SMITHKLINE BEECHAM CORP (US) | 1995-10-13 | — | — | EP | disclosed |
| WO-1994019354-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-09-01 | — | — | WO | disclosed |