Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28262324 | 0.96 | TDP1 (0.43) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL8927611 | 0.92 | APP (0.37) | APPTDP1ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL21979758 | 0.89 | ALDH1A1 (0.41) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL28396439 | 0.89 | NR4A1 (0.51) | TDP1MAPK1ALDH1A1CYP3A4KDM4E | |
| SCHEMBL28396440 | 0.89 | APP (0.36) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL9242278 | 0.87 | ALDH1A1 (0.41) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL10128556 | 0.85 | CYP1A2 (0.39) | TDP1ALDH1A1CYP3A4HPGDKDM4E | |
| SCHEMBL23064852 | 0.85 | ALDH1A1 (0.42) | TDP1MAPK1ALDH1A1CYP3A4HPGD | |
| SCHEMBL9427929 | 0.84 | CYP1A2 (0.38) | TDP1ALDH1A1CYP3A4HPGDKDM4E | |
| SCHEMBL14570743 | 0.84 | ACHE (0.42) | TDP1ALDH1A1CYP3A4HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631404-A | DIAMINE COMPOUND SUBSTITUTED WITH PYRENE RING, FLEXIBILITY | RICOH COMPANY, LTD. (JP) | 1997-05-20 | — | — | US | disclosed |
| US-5489495-A | Electrophotographic photoconductor and diamine compounds for use in the same | RICHOH COMPANY, LTD. (JP) | 1996-02-06 | — | — | US | disclosed |