Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.36 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.35 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.79 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175103 | 0.81 | GPR119 (0.57) | GPR119HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8927585 | 0.81 | GPR119 (0.57) | GPR119HTR1AALDH1A1KDM4EHRH3 | |
| SCHEMBL8931663 | 0.79 | GPR119 (0.55) | GPR119ALDH1A1KDM4EHTR3EHTR3B | |
| SCHEMBL22119850 | 0.78 | GPR119 (0.54) | GPR119CHRNB2CHRNA4OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL28627284 | 0.77 | GPR119 (0.53) | GPR119CHRNB2CHRNA4OPRM1OPRL1 | |
| SCHEMBL8931661 | 0.76 | GPR119 (0.52) | GPR119HTR1AHTR7HTR2BALDH1A1 | |
| SCHEMBL7878334 | 0.75 | SMN1; SMN2 (0.56) | GPR119HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8931671 | 0.75 | GPR119 (0.51) | GPR119ALDH1A1KDM4EHSD17B10USP2 | |
| SCHEMBL13114774 | 0.74 | GPR119 (0.49) | GPR119CHRNB2CHRNA4OPRM1OPRL1 | |
| SCHEMBL8931690 | 0.74 | GPR119 (0.58) | GPR119ALDH1A1HTR3EHTR3BADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607932-A | Heterocyclic derivatives of azolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-04 | — | — | US | disclosed |