Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.76 |
| ▸ | HTR2A | P28223 | 5/20 | 0.76 |
| ▸ | HTR1A | P08908 | 4/20 | 0.76 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.71 |
| ▸ | DRD2 | P14416 | 6/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.63 |
| ▸ | HRH2 | P25021 | 3/20 | 0.60 |
| ▸ | HRH1 | P35367 | 3/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 5/20 | 0.58 |
| ▸ | DRD1 | P21728 | 4/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994839 | 0.89 | DRD2 (0.67) | DRD4HTR2AHTR1AHRH4DRD2 | |
| SCHEMBL8928035 | 0.89 | HRH4 (0.62) | DRD4HTR2AHTR1AHRH4DRD2 | |
| SCHEMBL8928029 | 0.88 | DRD4 (0.61) | DRD4HTR2AHTR1AHRH4DRD2 | |
| SCHEMBL4192075 | 0.87 | HRH4 (0.83) | DRD4HTR2AHTR1AHRH4DRD2 | |
| Hydrochloric Acid SCHEMBL3838758 | 0.86 | HRH4 (0.81) | DRD4HTR2AHTR1AHRH4DRD2 | |
| SCHEMBL3855338 | 0.85 | HRH4 (0.77) | DRD4HTR2AHTR1AHRH4DRD2 | |
| SCHEMBL3834180 | 0.85 | HRH4 (0.73) | DRD4HTR2AHTR1AHRH4DRD2 | |
| SCHEMBL8928031 | 0.84 | HRH4 (0.61) | DRD4HTR2AHTR1AHRH4DRD2 | |
| SCHEMBL3836813 | 0.84 | HRH4 (0.74) | DRD4HTR2AHTR1AHRH4DRD2 | |
| Isoloxapine SCHEMBL2738975 | 0.83 | HRH4 (1.00) | DRD4HTR2AHTR1AHRH4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996018623-A1 | BENZYL-SUBSTITUTED COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (US) | 1996-06-20 | — | — | WO | claimed |
| US-5693251-A | LIQUID CRYSTAL DISPLAYS; HIGH SPEED RESPONSE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5625087-A | Silylium cationic polymerization activators for metallocene complexes | THE DOW CHEMICAL COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| US-5602120-A | ADMINISTERING FOR TREATING A CONDITION MEDIATED BY THE D4 RECEPTOR: SCHIZOPHRENIA | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1997-02-11 | — | — | US | disclosed |
| WO-1996018623-A1 | BENZYL-SUBSTITUTED COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (US) | 1996-06-20 | — | — | WO | disclosed |