Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068646 | 0.85 | ALDH1A1 (0.47) | MAPTKDM4ELMNAMAPK1KMT2A | |
| SCHEMBL1979077 | 0.83 | RAF1 (0.51) | MAPTKDM4ELMNAMAPK1KMT2A | |
| SCHEMBL27997380 | 0.81 | RAF1 (0.40) | MAPTKDM4ELMNAMAPK1KMT2A | |
| SCHEMBL8928555 | 0.75 | MAPT (0.46) | MAPTKDM4EKMT2ATSHRHSD17B10 | |
| SCHEMBL1371646 | 0.74 | KMT2A (0.42) | MAPTKDM4EMAPK1KMT2ATSHR | |
| SCHEMBL8801741 | 0.74 | MAPT (0.42) | MAPTKDM4EKMT2ATSHRHSD17B10 | |
| SCHEMBL14419258 | 0.74 | GAA (0.44) | MAPTKDM4EKMT2ATSHRHSD17B10 | |
| SCHEMBL13992671 | 0.72 | MAPT (0.41) | MAPTKDM4ELMNAMAPK1KMT2A | |
| SCHEMBL12750338 | 0.71 | MAPT (0.40) | MAPTKDM4ELMNAMAPK1KMT2A | |
| SCHEMBL4062812 | 0.70 | MAPT (0.42) | MAPTKDM4EKMT2ATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038535-A1 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMA (US) | 2015-02-05 | — | — | US | disclosed |
| US-8759389-B1 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-24 | — | — | US | disclosed |
| US-8399478-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-03-19 | — | — | US | disclosed |
| US-8188134-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110288095-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110178146-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038535-A1 | Thiophene-carboxamides useful as inhibitors of protein kinases | MAP3K20, ABL1, MAP3K5 | MAPT 1279/4885KDM4E 630/4885LMNA 3853/4885 |
| US-20110178146-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, ABL1, MAP3K5 | MAPT 1279/4885KDM4E 630/4885LMNA 3853/4885 |
| US-20110288095-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, ABL1, MAP3K5 | MAPT 1279/4885KDM4E 630/4885LMNA 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.