Acrylonitrile

Acrylonitrile

SCHEMBL8928577

C=CC#N.C=Cc1ccccc1C.CC=C(C)C(=O)O

nearest known ligand 0.37

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.37
ALDH1A1 P00352 5/20 0.36
TSHR P16473 2/20 0.36
KDM4E B2RXH2 4/20 0.35
LMNA P02545 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
GMNN O75496 1/20 0.35
PMP22 Q01453 1/20 0.35
KMT2A Q03164 2/20 0.34
PKM P14618 1/20 0.34
ACHE P22303 1/20 0.34
CYP2C9 P11712 1/20 0.33
APEX1 P27695 1/20 0.33
HTT P42858 3/20 0.32
MAPT P10636 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
HPGD P15428 2/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8928653 0.91 AKR1C3 (0.43) AKR1C3ALDH1A1TSHRKDM4ELMNA
SCHEMBL11880751 0.91 AKR1C3 (0.43) AKR1C3ALDH1A1TSHRKDM4ELMNA
Methacrylic Acid SCHEMBL27703285 0.86 ALDH1A1 (0.36) AKR1C3ALDH1A1TSHRKDM4ELMNA
Acrylonitrile SCHEMBL8511291 0.83 ALDH1A1 (0.45) ALDH1A1TSHRKDM4ESMN1; SMN2KMT2A
Styrene SCHEMBL301613 0.82 AKR1C3 (0.49) AKR1C3ALDH1A1TSHRKDM4ELMNA
SCHEMBL4865262 0.81 AKR1C3 (0.48) AKR1C3ALDH1A1KDM4ELMNACYP2C9
SCHEMBL7747003 0.81 AKR1C3 (0.48) AKR1C3ALDH1A1KDM4ELMNACYP2C9
Acrylonitrile SCHEMBL27824792 0.80 ALDH1A1 (0.37) ALDH1A1TSHRKDM4EACHEMAPT
Acrylonitrile SCHEMBL19691715 0.80 TSHR (0.42) ALDH1A1TSHRKDM4EKMT2AACHE
Styrene SCHEMBL4005344 0.79 AKR1C3 (0.46) AKR1C3ALDH1A1TSHRKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0555471-B1 METHOD OF OBTAINING POLYSTYRENE PLASTICS OKHTINSKOE N PROIZV OBIENINENI (RU) 1997-01-29 EP disclosed
US-5464915-A Calcium triphosphate stabilizers for addition polymerization PLASTPOLYMER SHARE HOLDING COMPANY (RU) 1995-11-07 US disclosed
EP-0555471-A1 METHOD OF OBTAINING POLYSTYRENE PLASTICS OKHTINSKOE NAUCHNO-PROIZVODSTVENNOE OBIENINENIE "PLASTOPOLIMER" (SU) 1993-08-18 EP disclosed