Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89318 | 1.00 | REN (0.52) | RENNTRK1KCNH2ALDH1A1 | |
| SCHEMBL89306 | 1.00 | REN (0.52) | RENNTRK1KCNH2ALDH1A1 | |
| SCHEMBL89375 | 1.00 | REN (0.52) | RENNTRK1KCNH2ALDH1A1 | |
| SCHEMBL90728 | 0.93 | REN (0.47) | RENNTRK1KCNH2ALDH1A1 | |
| SCHEMBL89540 | 0.89 | REN (0.53) | RENALDH1A1 | |
| SCHEMBL89940 | 0.89 | REN (0.41) | RENNTRK1ALDH1A1 | |
| SCHEMBL90677 | 0.89 | REN (0.41) | RENNTRK1ALDH1A1 | |
| SCHEMBL89800 | 0.89 | REN (0.41) | RENNTRK1ALDH1A1 | |
| SCHEMBL90076 | 0.89 | REN (0.41) | RENNTRK1ALDH1A1 | |
| SCHEMBL89525 | 0.88 | REN (0.51) | RENALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | REN 1/4885NTRK1 1586/4885KCNH2 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.