Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.63 |
| ▸ | TTBK1 | Q5TCY1 | 15/20 | 0.58 |
| ▸ | TTBK2 | Q6IQ55 | 15/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8928980 | 0.99 | EGFR (0.62) | EGFRTTBK1TTBK2AURKAAURKB | |
| SCHEMBL8929392 | 0.81 | EGFR (0.58) | EGFRTTBK1TTBK2AURKAAURKB | |
| Hydrochloric Acid SCHEMBL8929775 | 0.80 | EGFR (0.57) | EGFRTTBK1TTBK2AURKAAURKB | |
| SCHEMBL23408992 | 0.76 | TTBK1 (0.62) | EGFRTTBK1TTBK2AURKAAURKB | |
| SCHEMBL8929171 | 0.76 | BCL6 (0.60) | EGFRTTBK1TTBK2AURKAAURKB | |
| Hydrochloric Acid SCHEMBL8929519 | 0.75 | BCL6 (0.58) | EGFRTTBK1TTBK2AURKAAURKB | |
| SCHEMBL7021509 | 0.75 | EGFR (0.70) | EGFRTTBK1TTBK2AURKAAURKB | |
| SCHEMBL7832906 | 0.75 | EGFR (0.59) | EGFRLCK | |
| Hydrochloric Acid SCHEMBL7020471 | 0.74 | EGFR (0.69) | EGFRTTBK1TTBK2AURKAAURKB | |
| SCHEMBL16363320 | 0.74 | TTBK1 (0.84) | TTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |