Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 1/20 | 0.60 |
| ▸ | TTBK1 | Q5TCY1 | 14/20 | 0.52 |
| ▸ | TTBK2 | Q6IQ55 | 14/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8929519 | 0.99 | BCL6 (0.58) | BCL6TTBK1TTBK2EGFRAURKA | |
| SCHEMBL7822353 | 0.79 | BCL6 (0.57) | BCL6EGFRAURKAAURKBPTK2B | |
| Hydrochloric Acid SCHEMBL8477066 | 0.78 | BCL6 (0.56) | BCL6EGFRAURKAAURKBPTK2B | |
| SCHEMBL8929209 | 0.76 | EGFR (0.63) | TTBK1TTBK2EGFRAURKAAURKB | |
| SCHEMBL8929278 | 0.75 | TRPA1 (0.56) | BRAFTNNI3K | |
| SCHEMBL8930219 | 0.75 | SMYD3 (0.41) | BCL6PTK2 | |
| Hydrochloric Acid SCHEMBL8928980 | 0.75 | EGFR (0.62) | TTBK1TTBK2EGFRAURKAAURKB | |
| SCHEMBL12085389 | 0.75 | SYK (0.56) | BCL6PTK2BPTK2 | |
| SCHEMBL7821617 | 0.75 | EGFR (0.55) | BCL6EGFRPTK2BPTK2 | |
| Hydrochloric Acid SCHEMBL8474210 | 0.74 | EGFR (0.54) | BCL6EGFRPTK2BPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |