Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | AKT2 | P31751 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535805 | 0.77 | JAK3 (0.57) | CDC7DBF4JAK3AKT2NOTUM | |
| SCHEMBL8929835 | 0.73 | HPGDS (0.63) | JAK3HPGDSTTBK1TTBK2JAK1 | |
| Hydrochloric Acid SCHEMBL8929253 | 0.72 | HPGDS (0.61) | JAK3HPGDSTTBK1TTBK2JAK1 | |
| SCHEMBL8929293 | 0.72 | JAK3 (0.62) | JAK3AKT2KITGSK3BJAK2 | |
| SCHEMBL8929626 | 0.72 | CYP19A1 (0.46) | CDC7DBF4JAK3AKT2KIT | |
| SCHEMBL3530525 | 0.72 | JAK1 (0.67) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL1444372 | 0.69 | JAK3 (0.47) | CDC7DBF4JAK3AKT2NOTUM | |
| SCHEMBL6642228 | 0.68 | HPGDS (0.67) | JAK3HPGDSTTBK1TTBK2 | |
| SCHEMBL191691 | 0.66 | CDC7 (0.61) | CDC7DBF4JAK3NOTUMGSK3B | |
| SCHEMBL193515 | 0.66 | AURKA (0.57) | JAK3JAK2HPGDSTTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |