Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27540146 | 0.93 | — | — | |
| Bicarbonate SCHEMBL21220105 | 0.90 | — | — | |
| Bicarbonate SCHEMBL8929783 | 0.89 | — | — | |
| Bicarbonate SCHEMBL8929780 | 0.89 | CA1 (0.47) | — | |
| Acetic Acid SCHEMBL28015778 | 0.87 | CA1 (0.56) | — | |
| Acetic Acid SCHEMBL8206910 | 0.86 | — | — | |
| Acetic Acid SCHEMBL2186272 | 0.86 | CA1 (0.64) | — | |
| Acetic Acid SCHEMBL3173468 | 0.86 | — | — | |
| Acetic Acid SCHEMBL27839988 | 0.84 | CA1 (0.53) | — | |
| Acetic Acid SCHEMBL10534378 | 0.83 | CA1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344370-A | Isoindolinone and indazole compounds for EGFR degradation | C4医药公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-117279933-A | Cyclic compounds having selective KRAS inhibition relative to HRAS and NRAS | 中外制药株式会社 | 2023-12-22 | — | — | CN | disclosed |
| CN-109563043-A | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-108387674-A | A kind of assay method of double fluorine sulfimide lithium purity | 九江天赐高新材料有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-103265495-B | Multicyclic amino acid derivatives and using method thereof | 莱西肯医药有限公司 | 2016-11-16 | — | — | CN | disclosed |
| US-5605795-A | Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor | TROPIX, INC. (US) | 1997-02-25 | — | — | US | disclosed |
| CN-1033971-C | 9-[(substituted glycyl) amido]-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID CO (US) | 1997-02-05 | — | — | CN | disclosed |
| US-5220005-A | Reactable with enzyme to release optically detectable energy | TROPIX, INC. (US) | 1993-06-15 | — | — | US | disclosed |