SCHEMBL8930017

SCHEMBL8930017

CC(C)OC(=O)c1cc(NC(=O)c2ccccc2)c(F)cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.53
RAB9A P51151 5/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
MAPT P10636 3/20 0.53
HTT P42858 2/20 0.53
LMNA P02545 3/20 0.52
ALDH1A1 P00352 2/20 0.52
HDAC1 Q13547 4/20 0.48
HDAC8 Q9BY41 3/20 0.48
HDAC6 Q9UBN7 3/20 0.48
KDM4E B2RXH2 2/20 0.46
MAPK1 P28482 1/20 0.46
HSD17B10 Q99714 1/20 0.46
ACLY P53396 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
TP53 P04637 1/20 0.45
MAPK14 Q16539 1/20 0.43
NFKB1 P19838 1/20 0.43
NFKB2 Q00653 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10647200 0.84 MAPT (0.46) NPC1RAB9ASMN1; SMN2MAPTLMNA
SCHEMBL27309632 0.82 MEN1 (0.58) NPC1RAB9ASMN1; SMN2MAPTHTT
SCHEMBL9198085 0.80 SMN1; SMN2 (0.67) NPC1RAB9ASMN1; SMN2MAPTHTT
SCHEMBL9204064 0.80 SMN1; SMN2 (0.39) NPC1RAB9ASMN1; SMN2MAPTLMNA
SCHEMBL8930238 0.79 LMNA (0.44) NPC1RAB9ASMN1; SMN2MAPTHTT
SCHEMBL10421286 0.79 LMNA (0.42) SMN1; SMN2MAPTLMNA
SCHEMBL11020212 0.78 LMNA (0.48) NPC1RAB9ASMN1; SMN2MAPTLMNA
SCHEMBL11206454 0.77 NPSR1 (0.42) NPC1RAB9ASMN1; SMN2MAPTHTT
SCHEMBL13981047 0.76 LMNA (0.47) NPC1RAB9ASMN1; SMN2MAPTHTT
SCHEMBL9247954 0.76 HPGD (0.56) NPC1RAB9ASMN1; SMN2MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0497816-B1 TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN UNIROYAL CHEMICAL LTD (CA) 1995-05-17 EP claimed
EP-0497816-A1 TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN. UNIROYAL CHEMICAL LTD (CA) 1992-08-12 EP claimed
WO-1991005761-A1 TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN UNIROYAL CHEMICAL LTD./UNIROYAL CHEMICAL LTEE (CA) 1991-05-02 WO claimed
US-5693827-A Treatment of HIV infections and compounds useful therein UNIROYAL CHEMICAL COMPANY, INC. 1997-12-02 US disclosed
EP-0497816-B1 TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN UNIROYAL CHEMICAL LTD (CA) 1995-05-17 EP disclosed
US-5268389-A Containing a benzene ring UNIROYAL CHEMICAL COMPANY, INC. (US) 1993-12-07 US disclosed
EP-0497816-A1 TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN. UNIROYAL CHEMICAL LTD (CA) 1992-08-12 EP disclosed
WO-1991005761-A1 TREATMENT OF HIV INFECTIONS AND COMPOUNDS USEFUL THEREIN UNIROYAL CHEMICAL LTD./UNIROYAL CHEMICAL LTEE (CA) 1991-05-02 WO disclosed
CN-1051036-A The treatment of HIV (human immunodeficiency virus) infections and in treatment used compound UNIROYAL CHEM CO INC (US) 1991-05-01 CN disclosed