SCHEMBL8930149

SCHEMBL8930149

Cc1ccccc1NC(=O)C=Cc1c(O)c(=O)[nH]c2cc(Cl)ccc2c1=O

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 4/20 0.45
MMP2 P08253 4/20 0.45
MMP9 P14780 4/20 0.45
EGFR P00533 1/20 0.45
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ALOX15 P16050 2/20 0.42
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP2C9 P11712 1/20 0.41
HPGD P15428 1/20 0.41
GRIN2D O15399 1/20 0.41
GRIN3B O60391 1/20 0.41
GRIN1 Q05586 1/20 0.41
GRIN2A Q12879 1/20 0.41
GRIN2B Q13224 1/20 0.41
GRIN2C Q14957 1/20 0.41
GRIN3A Q8TCU5 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8548936 1.00 MMP1 (0.45) MMP1MMP2MMP9EGFRNPC1
SCHEMBL8549702 0.88 LPAR1 (0.41) EGFRALOX15GRIN2DGRIN3BGRIN1
SCHEMBL8929959 0.88 LPAR1 (0.41) EGFRALOX15GRIN2DGRIN3BGRIN1
SCHEMBL8930130 0.86 GPR17 (0.53) MMP1MMP2MMP9EGFRALOX15
SCHEMBL8546223 0.86 GPR17 (0.53) MMP1MMP2MMP9EGFRALOX15
SCHEMBL8547103 0.79 GRIN2D (0.48) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8548618 0.79 GRIN2D (0.48) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8549698 0.77 MAPT (0.49) EGFRNPC1RAB9ASMN1; SMN2ALOX15
SCHEMBL8929925 0.77 MAPT (0.49) EGFRNPC1RAB9ASMN1; SMN2ALOX15
SCHEMBL8547075 0.76 ALOX15 (0.49) ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5656626-A NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE ZENECA LIMITED (GB) 1997-08-12 US claimed
EP-0702673-A1 BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS ZENECA LIMITED (GB) 1996-03-27 EP claimed
WO-1994029275-A1 BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS ZENECA LIMITED (GB) 1994-12-22 WO claimed
US-5656626-A NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE ZENECA LIMITED (GB) 1997-08-12 US disclosed
EP-0702673-A1 BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS ZENECA LIMITED (GB) 1996-03-27 EP disclosed
WO-1994029275-A1 BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS ZENECA LIMITED (GB) 1994-12-22 WO disclosed