Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548913 | 1.00 | EGFR (0.43) | EGFRALDH1A1CYP2C19MEN1LMNA | |
| SCHEMBL8722402 | 0.82 | GPR17 (0.49) | EGFRALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL8549040 | 0.82 | GPR17 (0.49) | EGFRALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL8930074 | 0.81 | LPAR1 (0.46) | ALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL8548709 | 0.81 | LPAR1 (0.46) | ALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL8544547 | 0.81 | ALOX15 (0.41) | EGFRALOX15PARP1 | |
| SCHEMBL8544259 | 0.80 | TUBB4A (0.43) | MEN1LMNAKMT2AALOX15MAPK1 | |
| SCHEMBL8544261 | 0.80 | TUBB4A (0.43) | MEN1LMNAKMT2AALOX15MAPK1 | |
| SCHEMBL8930082 | 0.78 | MAPT (0.48) | EGFRALDH1A1CYP2C19MEN1LMNA | |
| SCHEMBL8721619 | 0.78 | MAPT (0.48) | EGFRALDH1A1CYP2C19MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656626-A | NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE | ZENECA LIMITED (GB) | 1997-08-12 | — | — | US | claimed |
| US-5656626-A | NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE | ZENECA LIMITED (GB) | 1997-08-12 | — | — | US | disclosed |
| EP-0702673-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1996-03-27 | — | — | EP | disclosed |
| WO-1994029275-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | disclosed |