Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 1.00 |
| ▸ | ABL1 | P00519 | 8/20 | 1.00 |
| ▸ | ABL2 | P42684 | 8/20 | 1.00 |
| ▸ | SRC | P12931 | 15/20 | 0.82 |
| ▸ | LCK | P06239 | 4/20 | 0.82 |
| ▸ | KDR | P35968 | 4/20 | 0.82 |
| ▸ | TEK | Q02763 | 3/20 | 0.82 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.82 |
| ▸ | PRKCG | P05129 | 1/20 | 0.82 |
| ▸ | PRKCB | P05771 | 1/20 | 0.82 |
| ▸ | PRKCA | P17252 | 1/20 | 0.82 |
| ▸ | PRKCH | P24723 | 1/20 | 0.82 |
| ▸ | PRKCI | P41743 | 1/20 | 0.82 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.82 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.82 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.82 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.82 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.82 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.73 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6861201 | 0.91 | SRC (1.00) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL132510 | 0.84 | SRC (1.00) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL2075318 | 0.84 | SRC (0.89) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL8128439 | 0.83 | LCK (0.85) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL28928810 | 0.83 | EGFR (0.71) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL28928811 | 0.83 | EGFR (0.71) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL5936173 | 0.83 | SRC (0.97) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL24458410 | 0.82 | LCK (0.88) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL24458713 | 0.82 | LCK (0.88) | EGFRABL1ABL2SRCLCK | |
| SCHEMBL24458415 | 0.82 | LCK (0.88) | EGFRABL1ABL2SRCLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997028161-A1 | NOVEL PYRROLO[2,3-D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 1997-08-07 | — | — | WO | disclosed |