Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27429818 | 0.91 | GSK3B (0.49) | GSK3BCHRNB2CHRNA4CHRM2CHRM1 | |
| SCHEMBL5755963 | 0.83 | DDB1 (0.57) | CTSDDDB1CRBN | |
| Hydrochloric Acid SCHEMBL15650706 | 0.81 | DDB1 (0.55) | CTSDDDB1CRBN | |
| SCHEMBL2729166 | 0.78 | DDB1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4961020 | 0.75 | ALDH1A1 (0.50) | ALDH1A1PDE4DDDB1CRBN | |
| SCHEMBL22144656 | 0.75 | GSK3B (0.51) | GSK3BCHRNB2CHRNA4CTSDCHRNA7 | |
| SCHEMBL2981954 | 0.74 | POLB (0.58) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL5753552 | 0.74 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6104351 | 0.74 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31296370 | 0.74 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602257-A | Synthesis of nicotinic analogs | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 1997-02-11 | — | — | US | claimed |