Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9280234 | 0.86 | SIGMAR1 (0.40) | SIGMAR1POLBABCB1HRH3HTR2A | |
| SCHEMBL7144048 | 0.85 | HRH1 (0.34) | HRH3HRH1 | |
| SCHEMBL7144620 | 0.82 | HRH1 (0.38) | HTR2AKCNH2MAPTKCNA5LMNA | |
| SCHEMBL9284502 | 0.81 | HRH1 (0.43) | POLBHTR2AKCNH2MAPTLMNA | |
| SCHEMBL9234670 | 0.80 | SIGMAR1 (0.41) | SIGMAR1POLBABCB1HRH3HTR2A | |
| Water SCHEMBL7159274 | 0.80 | HRH1 (0.43) | POLBHTR2AKCNH2MAPTLMNA | |
| SCHEMBL7139908 | 0.79 | UTS2R (0.35) | HTR2AOPRM1LMNAHRH1 | |
| SCHEMBL7139634 | 0.79 | HRH1 (0.34) | HTR2AKCNH2KCNA5HRH1 | |
| SCHEMBL7136336 | 0.79 | HRH1 (0.38) | HTR2AKCNH2LMNAHRH1 | |
| SCHEMBL7139912 | 0.77 | HRH1 (0.44) | HTR2AKCNH2MAPTOPRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629308-A | Imidazo [1,2-A] (pyrrolo, thieno or furano) [2,3-D] azepine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-13 | — | — | US | disclosed |