⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931384 | 0.82 | ALDH1A1 (0.40) | — | |
| SCHEMBL27748701 | 0.72 | — | — | |
| SCHEMBL8931338 | 0.71 | CYP1A2 (0.44) | — | |
| SCHEMBL8931358 | 0.67 | ALDH1A1 (0.53) | — | |
| SCHEMBL8931362 | 0.65 | — | — | |
| SCHEMBL2614500 | 0.63 | — | — | |
| SCHEMBL5154036 | 0.63 | — | — | |
| SCHEMBL5153603 | 0.60 | — | — | |
| SCHEMBL28320492 | 0.60 | — | — | |
| SCHEMBL11150044 | 0.59 | ALDH1A1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648498-A | Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof | ASTRA AKTIEBOLAG (SE) | 1997-07-15 | — | — | US | claimed |
| EP-0619815-B1 | PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF | ASTRA AB (SE) | 1997-04-16 | — | — | EP | claimed |
| EP-0546306-B1 | 5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation | ASTRA AB (SE) | 1997-04-16 | — | — | EP | claimed |
| EP-0619815-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF. | ASTRA AB (SE) | 1994-10-19 | — | — | EP | claimed |
| EP-0546306-A1 | 5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation | Astra Aktiebolag (SE) | 1993-06-16 | — | — | EP | claimed |
| WO-1993009107-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF | AKTIEBOLAGET ASTRA (SE) | 1993-05-13 | — | — | WO | claimed |
| US-5648498-A | Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof | ASTRA AKTIEBOLAG (SE) | 1997-07-15 | — | — | US | disclosed |
| EP-0619815-B1 | PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF | ASTRA AB (SE) | 1997-04-16 | — | — | EP | disclosed |
| EP-0619815-B1 | PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF | ASTRA AB (SE) | 1997-04-16 | — | — | EP | disclosed |
| EP-0546306-B1 | 5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation | ASTRA AB (SE) | 1997-04-16 | — | — | EP | disclosed |
| US-5534644-A | Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof | AKTIEBOLAGET ASTRA (SE) | 1996-07-09 | — | — | US | disclosed |
| US-5534644-A | Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof | AKTIEBOLAGET ASTRA (SE) | 1996-07-09 | — | — | US | disclosed |
| EP-0619815-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF. | ASTRA AB (SE) | 1994-10-19 | — | — | EP | disclosed |
| EP-0619815-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF. | ASTRA AB (SE) | 1994-10-19 | — | — | EP | disclosed |
| EP-0546306-A1 | 5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation | Astra Aktiebolag (SE) | 1993-06-16 | — | — | EP | disclosed |
| EP-0546306-A1 | 5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation | Astra Aktiebolag (SE) | 1993-06-16 | — | — | EP | disclosed |
| WO-1993009107-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF | AKTIEBOLAGET ASTRA (SE) | 1993-05-13 | — | — | WO | disclosed |
| WO-1993009107-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROETHYL)-THIAZOLE AND ANALOGUES THEREOF | AKTIEBOLAGET ASTRA (SE) | 1993-05-13 | — | — | WO | disclosed |