SCHEMBL8931704

SCHEMBL8931704

CCC(C(O)c1ccc(Cl)cc1)n1ncn(-c2ccc(N3CCN(c4cccc(OC)c4)CC3)nc2)c1=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 2/20 0.57
MAPT P10636 4/20 0.45
MAPK1 P28482 1/20 0.41
DRD4 P21917 3/20 0.41
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
CYP3A4 P08684 2/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
DRD2 P14416 3/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
ADRA2C P18825 1/20 0.38
HRH2 P25021 1/20 0.38
HTR1B P28222 1/20 0.38
HTR2A P28223 1/20 0.38
HTR7 P34969 1/20 0.38
ADRA1A P35348 1/20 0.38
HRH1 P35367 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9285138 1.00 DGAT1 (0.57) DGAT1MAPTMAPK1DRD4ALDH1A1
SCHEMBL9286915 0.94 DGAT1 (0.50) DGAT1MAPTMAPK1DRD4ALDH1A1
SCHEMBL9286918 0.94 DGAT1 (0.50) DGAT1MAPTMAPK1DRD4ALDH1A1
SCHEMBL8931765 0.91 DGAT1 (0.60) DGAT1MAPTMAPK1ALDH1A1KDM4E
SCHEMBL9279579 0.91 DGAT1 (0.60) DGAT1MAPTMAPK1ALDH1A1KDM4E
SCHEMBL8931656 0.90 DGAT1 (0.54) DGAT1MAPTALDH1A1KDM4ESMN1; SMN2
SCHEMBL9285996 0.90 DGAT1 (0.54) DGAT1MAPTALDH1A1KDM4ESMN1; SMN2
SCHEMBL8815535 0.90 DGAT1 (0.53) DGAT1MAPTMAPK1DRD4ALDH1A1
SCHEMBL8931756 0.89 DGAT1 (0.60) DGAT1MAPTMAPK1ALDH1A1KDM4E
SCHEMBL8931684 0.86 DGAT1 (0.60) DGAT1MAPTDRD4ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5650411-A BACTERICIDES FOR HELICOBACTER DISEASES AND BACTERIA RESISTANCE JANSSEN PHARMACEUTICA N.V. (BE) 1997-07-22 US claimed
EP-0684821-A1 SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER JANSSEN PHARMACEUTICA N.V. (BE) 1995-12-06 EP claimed
WO-1994018978-A1 SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER JANSSEN PHARMACEUTICA N.V. (BE) 1994-09-01 WO claimed
US-5650411-A BACTERICIDES FOR HELICOBACTER DISEASES AND BACTERIA RESISTANCE JANSSEN PHARMACEUTICA N.V. (BE) 1997-07-22 US disclosed
EP-0684821-A1 SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER JANSSEN PHARMACEUTICA N.V. (BE) 1995-12-06 EP disclosed
WO-1994018978-A1 SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER JANSSEN PHARMACEUTICA N.V. (BE) 1994-09-01 WO disclosed