SCHEMBL8932579

SCHEMBL8932579

COC(=O)Cc1ccccc1CONC(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.58
NPC1 O15118 8/20 0.58
NPSR1 Q6W5P4 1/20 0.45
HDAC8 Q9BY41 3/20 0.44
HDAC6 Q9UBN7 3/20 0.44
HDAC3 O15379 2/20 0.44
HDAC4 P56524 2/20 0.44
HDAC1 Q13547 2/20 0.44
HDAC7 Q8WUI4 2/20 0.44
HDAC2 Q92769 2/20 0.44
HDAC10 Q969S8 2/20 0.44
HDAC11 Q96DB2 2/20 0.44
HDAC9 Q9UKV0 2/20 0.44
HDAC5 Q9UQL6 2/20 0.44
CFD P00746 1/20 0.44
ALDH1A1 P00352 3/20 0.42
POLB P06746 1/20 0.42
MAPT P10636 1/20 0.42
KMT2A Q03164 1/20 0.42
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1554320 0.79 KDM4E (0.53) CFDALDH1A1POLBMAPTHPGD
SCHEMBL3636010 0.78 RAB9A (0.65) RAB9ANPC1HDAC8HDAC6HDAC3
SCHEMBL7929984 0.77 KDM4E (0.47) ALDH1A1POLBMAPT
SCHEMBL5718379 0.77 NPC1 (0.63) RAB9ANPC1HDAC8HDAC6HDAC3
Hydrochloric Acid SCHEMBL8484869 0.76 IDO1 (0.51) ALDH1A1MAPT
SCHEMBL3816268 0.76 NPC1 (0.61) RAB9ANPC1HDAC8HDAC6HDAC3
SCHEMBL1958849 0.76 AKR1B1 (0.55) ALDH1A1POLB
SCHEMBL5842246 0.74 CFD (0.48) CFDALDH1A1POLBMAPTKMT2A
SCHEMBL5120704 0.74 RAB9A (1.00) RAB9ANPC1HDAC8HDAC6HDAC3
SCHEMBL11972779 0.73 KDM4E (0.49) ALDH1A1POLBMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996026191-A1 FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-08-29 WO disclosed