Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.45 |
| ▸ | KIF11 | P52732 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL9856999 | 1.00 | CYP2D6 (0.45) | CYP2D6MAPK1GRIK1KIF11ALDH1A1 | |
| Aspartic Acid SCHEMBL10590014 | 0.91 | KDM4E (0.47) | CYP2D6MAPK1GRIK1KIF11ALDH1A1 | |
| Aspartic Acid SCHEMBL10590016 | 0.91 | KDM4E (0.47) | CYP2D6MAPK1GRIK1KIF11ALDH1A1 | |
| Glutamic Acid SCHEMBL4697460 | 0.88 | KIF11 (0.45) | CYP2D6MAPK1GRIK1KIF11ALDH1A1 | |
| D-Glutamate SCHEMBL7902663 | 0.88 | KIF11 (0.45) | CYP2D6MAPK1GRIK1KIF11ALDH1A1 | |
| D-Glutamate SCHEMBL4692007 | 0.88 | KIF11 (0.45) | CYP2D6MAPK1GRIK1KIF11ALDH1A1 | |
| Phenylalanine SCHEMBL10429981 | 0.84 | SLC7A5 (0.63) | CYP2D6MAPK1KIF11ALDH1A1BCHE | |
| Dl-Phenylalanine SCHEMBL28023088 | 0.84 | SLC7A5 (0.63) | CYP2D6MAPK1KIF11ALDH1A1BCHE | |
| Aspartic Acid SCHEMBL538084 | 0.83 | TSHR (0.55) | GRIK1ALPIPKMPTGS1XIAP | |
| Aspartic Acid SCHEMBL538085 | 0.83 | TSHR (0.55) | GRIK1ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107353409-B | Dendritic polymer compound and preparation method and application thereof | 安徽丰原药业股份有限公司 | 2020-04-24 | — | — | CN | claimed |
| CN-107353409-B | Dendritic polymer compound and preparation method and application thereof | 安徽丰原药业股份有限公司 | 2020-04-24 | — | — | CN | disclosed |
| US-5578725-A | NARCOTIC PEPTIDES FOR CENTRAL NERVOUS SYSTEM DISORDERS AND AUTOIMMUNE DISEASES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1996-11-26 | — | — | US | disclosed |
| WO-1996023793-A1 | DELTA OPIOID RECEPTOR ANTAGONISTS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1996-08-08 | — | — | WO | disclosed |