SCHEMBL8933063

SCHEMBL8933063

N=C(N)c1ccc(CNC(=O)[C@]2(C3CCCCC3)CCCN2C(=O)CN=CC(=O)O)c(Cl)c1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 7/20 0.34
F2 P00734 9/20 0.33
EPHX2 P34913 1/20 0.33
AKT1 P31749 1/20 0.32
AKT2 P31751 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8933084 0.92 F2 (0.33) F2
SCHEMBL8721666 0.89 F2 (0.35) F2MEN1KMT2A
SCHEMBL6475562 0.85 F2 (0.38) P2RX7F2EPHX2
SCHEMBL8726018 0.80 F2 (0.33) F2EPHX2MEN1KMT2A
Hydrochloric Acid SCHEMBL8721658 0.78 F2 (0.40) F2
SCHEMBL6483869 0.78 F2 (0.35) F2
SCHEMBL8723707 0.77 F2 (0.35) F2
SCHEMBL6475472 0.77 F2 (0.35) F2
SCHEMBL6477095 0.76 F2 (0.38) F2
SCHEMBL8727226 0.76 F2 (0.34) F2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996025426-A1 NOVEL DIPEPTIDE AMIDINES AS THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1996-08-22 WO disclosed