Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MGAM | O43451 | 2/20 | 0.40 |
| ▸ | SI | P14410 | 2/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8933557 | 1.00 | IGF1R (0.44) | IGF1REGFRPIM1PIM3PIM2 | |
| SCHEMBL8307815 | 0.85 | DYRK1A (0.61) | IGF1RPIM1PIM3PIM2DYRK1A | |
| SCHEMBL8307819 | 0.85 | DYRK1A (0.61) | IGF1RPIM1PIM3PIM2DYRK1A | |
| SCHEMBL8933490 | 0.82 | GAA (0.40) | IGF1REGFRPIM1PIM3PIM2 | |
| SCHEMBL8991940 | 0.82 | GAA (0.40) | IGF1REGFRPIM1PIM3PIM2 | |
| SCHEMBL8537292 | 0.80 | GAA (0.38) | IGF1REGFRPIM1PIM3PIM2 | |
| SCHEMBL8537293 | 0.80 | GAA (0.38) | IGF1REGFRPIM1PIM3PIM2 | |
| SCHEMBL8535804 | 0.80 | GAA (0.38) | IGF1REGFRPIM1PIM3PIM2 | |
| SCHEMBL8933559 | 0.78 | IGF1R (0.45) | IGF1REGFRPIM1PIM3PIM2 | |
| SCHEMBL8310599 | 0.78 | MAPT (0.56) | GAAKMT2AALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022772-A1 | METHOD FOR TREATING MULTIPLE SCLEROSIS | ELI LILLY AND COMPANY (US) | 1996-08-01 | — | — | WO | disclosed |
| EP-0722729-A2 | Aryl-substituted rhodanines for treating multiple sclerosis | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |