Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.37 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307820 | 0.84 | DYRK1A (0.61) | IGF1RPIM1PIM3PIM2DYRK1A | |
| SCHEMBL8933494 | 0.82 | IGF1R (0.40) | IGF1RPIM1PIM3PIM2DYRK1A | |
| SCHEMBL8537294 | 0.80 | IGF1R (0.38) | IGF1RPIM1PIM3PIM2DYRK1A | |
| SCHEMBL8933553 | 0.78 | IGF1R (0.44) | IGF1RPIM1PIM3PIM2DYRK1A | |
| SCHEMBL8933557 | 0.78 | IGF1R (0.44) | IGF1RPIM1PIM3PIM2DYRK1A | |
| SCHEMBL8310606 | 0.77 | MAPT (0.56) | MEN1KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL8933462 | 0.75 | FABP4 (0.47) | PDE4BMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8584348 | 0.69 | GAA (0.36) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL8534279 | 0.66 | CYP1A2 (0.41) | IGF1RPIM1PIM3PIM2ALOX5 | |
| SCHEMBL8534281 | 0.66 | CYP1A2 (0.41) | IGF1RPIM1PIM3PIM2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022772-A1 | METHOD FOR TREATING MULTIPLE SCLEROSIS | ELI LILLY AND COMPANY (US) | 1996-08-01 | — | — | WO | disclosed |
| EP-0722729-A2 | Aryl-substituted rhodanines for treating multiple sclerosis | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |