Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.88 |
| ▸ | FLT1 | P17948 | 1/20 | 0.88 |
| ▸ | EGFR | P00533 | 16/20 | 0.80 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.80 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.80 |
| ▸ | LCK | P06239 | 6/20 | 0.77 |
| ▸ | RET | P07949 | 3/20 | 0.67 |
| ▸ | GAK | O14976 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 1/20 | 0.67 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.67 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.67 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.67 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.67 |
| ▸ | FBP1 | P09467 | 2/20 | 0.67 |
| ▸ | CLK1 | P49759 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8808201 | 0.99 | KDR (0.86) | KDRFLT1EGFRRIPK2EPHB2 | |
| SCHEMBL5477771 | 0.94 | KDR (1.00) | KDRFLT1EGFRRIPK2LCK | |
| Hydrochloric Acid SCHEMBL5473772 | 0.92 | KDR (0.97) | KDRFLT1EGFRRIPK2LCK | |
| SCHEMBL18158232 | 0.90 | KDR (0.75) | KDRFLT1EGFRRIPK2EPHB2 | |
| SCHEMBL1387206 | 0.89 | EGFR (1.00) | KDRFLT1EGFRRIPK2EPHB2 | |
| SCHEMBL29385451 | 0.89 | EGFR (1.00) | KDRFLT1EGFRRIPK2EPHB2 | |
| Hydrochloric Acid SCHEMBL8811345 | 0.89 | KDR (0.73) | KDRFLT1EGFRRIPK2EPHB2 | |
| SCHEMBL18158594 | 0.88 | EGFR (0.80) | KDRFLT1EGFRRIPK2EPHB2 | |
| Hydrochloric Acid SCHEMBL8807925 | 0.88 | EGFR (0.98) | KDRFLT1EGFRRIPK2EPHB2 | |
| SCHEMBL5472599 | 0.87 | EGFR (1.00) | KDRFLT1EGFRRIPK2EPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996009294-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |