SCHEMBL29385451

SCHEMBL29385451

COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 15/20 1.00
RIPK2 O43353 2/20 1.00
EPHB2 P29323 1/20 1.00
KDR P35968 6/20 0.81
RET P07949 3/20 0.81
LCK P06239 5/20 0.79
SRC P12931 1/20 0.70
ERBB2 P04626 1/20 0.69
ERBB4 Q15303 1/20 0.69
FLT1 P17948 1/20 0.69
GAK O14976 1/20 0.69
STK10 O94804 1/20 0.69
FLT3 P36888 1/20 0.69
JAK3 P52333 1/20 0.69
AAK1 Q2M2I8 1/20 0.69
Q6ZSR9 Q6ZSR9 1/20 0.69
SLK Q9H2G2 1/20 0.69
IRAK4 Q9NWZ3 1/20 0.69
RPS6KA6 Q9UK32 1/20 0.69
ALK Q9UM73 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1387206 1.00 EGFR (1.00) EGFRRIPK2EPHB2KDRRET
Hydrochloric Acid SCHEMBL8807925 0.99 EGFR (0.98) EGFRRIPK2EPHB2KDRRET
SCHEMBL21442463 0.92 EGFR (0.84) EGFRRIPK2EPHB2KDRRET
SCHEMBL15390777 0.91 EGFR (0.83) EGFRRIPK2EPHB2KDRRET
SCHEMBL18158215 0.90 EGFR (0.82) EGFRRIPK2EPHB2KDRRET
SCHEMBL1387182 0.90 EGFR (0.94) EGFRRIPK2EPHB2KDRRET
SCHEMBL29515328 0.90 EGFR (1.00) EGFRRIPK2EPHB2KDRRET
SCHEMBL1257431 0.90 EGFR (1.00) EGFRRIPK2EPHB2KDRRET
Hydrochloric Acid SCHEMBL8811926 0.89 EGFR (0.80) EGFRRIPK2EPHB2KDRRET
SCHEMBL8933814 0.89 KDR (0.88) EGFRRIPK2EPHB2KDRRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119854122-A Dynamic optimization system and method for monitoring strategy of voice video local area network 华能龙开口水电有限公司 2025-04-18 CN claimed
CN-119696759-A Editable medical block chain system with privacy protection function 福建师范大学 2025-03-25 CN claimed
CN-118509262-B Lightweight forward-backward secure public key authentication encryption keyword searching method and system 青岛大学 2024-11-15 CN claimed
CN-118917390-A Knowledge base management system and method based on knowledge big model 中国标准化研究院 2024-11-08 CN claimed
CN-118573399-A Concealed communication method based on bit coin payment system 中国人民武装警察部队工程大学 2024-08-30 CN claimed
CN-116886311-B Policy signature method, system and storage medium based on blockchain privacy security 三未信安科技股份有限公司 2024-08-16 CN claimed
US-20230364086-A1 COMBINATION THERAPIES WITH EHMT2 INHIBITORS Epizyme, Inc. 2023-11-16 US claimed
CN-114677218-A Off-link transaction method based on payment knot 南京邮电大学 2022-06-28 CN claimed
CN-113422685-B Certificateless searchable public key encryption method and system for time-limited revocation of search token 南京师范大学 2022-06-24 CN claimed
US-20260146252-A1 COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS IONIS PHARMACEUTICALS, INC. (US) 2026-05-28 US disclosed
CN-122024473-A Road right management and control method, device, storage medium and program product 浙江吉利控股集团有限公司 2026-05-12 CN disclosed
US-20260085107-A1 PRODUCTION OF PROTEINS, INCLUDING SECRETED PROTEINS GINKGO BIOWORKS, INC. (US) 2026-03-26 US disclosed
EP-4711459-A2 CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE Ionis Pharmaceuticals, Inc. (US) 2026-03-18 EP disclosed
US-20260048133-A1 METHODS AND COMPOSITIONS USING PEPTIDES AND PROTEINS WITH C-TERMINAL ELEMENTS SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST (US) 2026-02-19 US disclosed
US-20220098663-A1 BIOMARKERS FOR CONGENITAL VASCULAR MALFORMATIONS UNIVERSITY OF SOUTH CAROLINA (US) 2022-03-31 US disclosed
US-20220089696-A1 ARENAVIRUS MONOCLONAL ANTIBODIES AND USES ZALGEN LABS, LLC 2022-03-24 US disclosed
US-20220062404-A1 GP38-TARGETING MONOCLONAL ANTIBODIES PROTECT ADULT MICE AGAINST LETHAL CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS INFECTION THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2022-03-03 US disclosed
US-11260133-B2 Methods and compositions related to peptides and proteins with C-terminal elements SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) 2022-03-01 US disclosed
CN-114058617-A Conjugated antisense compounds and uses thereof IONIS制药公司 2022-02-18 CN disclosed
US-20220049017-A1 ANTAGONISTS KYMAB LIMITED (GB) 2022-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260146252-A1 COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS SI, FABP2, FUT6 EGFR 2386/4885RIPK2 4605/4885EPHB2 1965/4885
US-20230364086-A1 COMBINATION THERAPIES WITH EHMT2 INHIBITORS EHMT2, BHMT, SHMT2 EGFR 1887/4885RIPK2 3348/4885EPHB2 336/4885
US-11260133-B2 Methods and compositions related to peptides and proteins with C-terminal elements CD2BP2, CLTC, CLTA EGFR 234/4885RIPK2 2858/4885EPHB2 1451/4885
US-20260048133-A1 METHODS AND COMPOSITIONS USING PEPTIDES AND PROTEINS WITH C-TERMINAL ELEMENTS CMKLR2, CRKL, CMKLR1 EGFR 14/4885RIPK2 1031/4885EPHB2 1341/4885
US-20260085107-A1 PRODUCTION OF PROTEINS, INCLUDING SECRETED PROTEINS HSPA5, UPF1, PDIA6 EGFR 3853/4885RIPK2 4602/4885EPHB2 3842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.