⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28724578 | 1.00 | — | — | |
| SCHEMBL3795375 | 1.00 | — | — | |
| SCHEMBL19204118 | 0.76 | LMNA (0.33) | — | |
| SCHEMBL5075041 | 0.74 | — | — | |
| SCHEMBL14191652 | 0.74 | — | — | |
| SCHEMBL1223513 | 0.74 | — | — | |
| SCHEMBL360722 | 0.74 | — | — | |
| SCHEMBL17641688 | 0.74 | — | — | |
| SCHEMBL14853052 | 0.74 | — | — | |
| SCHEMBL12952000 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039663-B1 | PROCESS FOR PREPARING CROSSLINKED SATURATED POLYMERS, AND THESE POLYMERS | CIBA-GEIGY AG (CH) | 1985-08-28 | — | — | EP | claimed |
| JP-8040904-A | — | — | None | — | — | JP | disclosed |
| US-20240391931-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2024-11-28 | — | — | US | disclosed |
| EP-4380941-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117980309-A | Tricyclic fused pyrimidine compounds useful as HER2 inhibitors | 百时美施贵宝公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023015240-A1 | TRICYCLIC FUSED PYRIMIDINE COMPOUNDS FOR USE AS HER2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-09 | — | — | WO | disclosed |
| WO-2021104340-A1 | SUBSTITUTED CROTONAMIDE PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR | 江苏苏中药业集团股份有限公司 | 2021-06-03 | — | — | WO | disclosed |
| US-20170001949-A1 | NOVEL CANNABINOID RECEPTOR 2 (CB2) INVERSE AGONISTS AND THERAPEUTIC POTENTIAL FOR MULTIPLE MYELOMA AND OSTEOPOROSIS BONE DISEASES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-01-05 | — | — | US | disclosed |
| JP-H0840904-A | 1,4-DIHYDROPYRIDINE COMPOUND | NIKKEN CHEM CO LTD | 1996-02-13 | — | — | JP | disclosed |
| EP-0457129-B1 | Process for the preparation of amine-terminated compounds | MILES INC (US) | 1995-01-18 | — | — | EP | disclosed |
| EP-0457129-A2 | Process for the preparation of amine-terminated compounds | MILES INC. (US) | 1991-11-21 | — | — | EP | disclosed |
| US-5066824-A | Polyhydroxy compound or polymer esterified with acetoacetic acid, then reacted with amine | MOBAY CORPORATION (US) | 1991-11-19 | — | — | US | disclosed |
| EP-0266989-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1990-07-04 | — | — | EP | disclosed |
| EP-0362770-A2 | Dry strength additive for paper | HERCULES INCORPORATED (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4788205-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR | PFIZER INC. (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0288628-A1 | Process for producing 2-methyl-3-carbamido-quinoxaline-1, 4-di-n-oxides | Chisso Corporation (JP) | 1988-11-02 | — | — | EP | disclosed |
| EP-0258033-A2 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1988-03-02 | — | — | EP | disclosed |
| EP-0220653-A2 | 3-Aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds, process for preparation and use thereof, and pharmaceutical composition containing the same | Nippon Shoji Kabushiki Kaisha (JP) | 1987-05-06 | — | — | EP | disclosed |