Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8934358 | 0.85 | TNFSF11 (0.53) | ALDH1A1KDM4ESIGMAR1KCNJ1KCNH2 | |
| Hydrochloric Acid SCHEMBL8934357 | 0.82 | HPGD (0.48) | ALDH1A1KDM4ESIGMAR1KCNJ1KCNH2 | |
| SCHEMBL5357196 | 0.80 | HTR1A (0.56) | ALDH1A1SLC6A9CYP2C9CYP2C19HTR2B | |
| Hydrochloric Acid SCHEMBL8934418 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4ECYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL1221164 | 0.75 | SCD (0.54) | ALDH1A1SLC6A9CYP2C9CYP2C19HTR2B | |
| SCHEMBL1096044 | 0.73 | SCD (0.57) | ALDH1A1KDM4ESLC6A9SCDMEN1 | |
| SCHEMBL223297 | 0.73 | CYP2C9 (0.65) | ALDH1A1KDM4ECYP2C9CYP2C19HTR2B | |
| SCHEMBL15687788 | 0.72 | KMT2A (0.58) | ALDH1A1SLC6A9MEN1KMT2ALMNA | |
| SCHEMBL20569608 | 0.72 | KMT2A (0.58) | ALDH1A1SLC6A9MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL8934402 | 0.71 | KDM4E (0.57) | ALDH1A1KDM4ESIGMAR1KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996015792-A1 | METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE USING SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES | MOLECULAR GERIATRICS CORPORATION (US) | 1996-05-30 | — | — | WO | claimed |
| WO-1996015792-A1 | METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE USING SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES | MOLECULAR GERIATRICS CORPORATION (US) | 1996-05-30 | — | — | WO | disclosed |