Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855273 | 0.89 | TSHR (0.61) | TSHRKCNH2KCNJ1MAPK1ALDH1A1 | |
| SCHEMBL135651 | 0.84 | TSHR (0.59) | TSHRKCNH2KCNJ1MAPK1ALDH1A1 | |
| SCHEMBL2850348 | 0.84 | TSHR (0.59) | TSHRKCNH2KCNJ1ALDH1A1MAPT | |
| SCHEMBL29465190 | 0.83 | PKM (0.43) | TSHRMAPK1ALDH1A1MAPTKMT2A | |
| SCHEMBL8813056 | 0.83 | TSHR (0.58) | TSHRKCNH2KCNJ1ALDH1A1MAPT | |
| SCHEMBL7733298 | 0.83 | TSHR (0.58) | TSHRKCNH2KCNJ1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5030930 | 0.83 | TSHR (0.58) | TSHRKCNH2KCNJ1MAPK1ALDH1A1 | |
| SCHEMBL5030925 | 0.83 | TSHR (0.58) | TSHRKCNH2KCNJ1ALDH1A1MAPT | |
| SCHEMBL9763373 | 0.82 | TSHR (0.46) | TSHRKCNH2MAPK1ALDH1A1MAPT | |
| SCHEMBL29318769 | 0.82 | TSHR (0.53) | TSHRKCNH2KCNJ1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996030350-A1 | AMIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-03 | — | — | WO | disclosed |
| EP-0178874-B1 | ALKYLSULFONAMIDOPHENYLALKYLAMINES | ELI LILLY AND COMPANY (US) | 1989-04-05 | — | — | EP | disclosed |
| US-4596827-A | Antiarrhythmia agents | ELI LILLY AND COMPANY (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0178874-A1 | Alkylsulfonamidophenylalkylamines | ELI LILLY AND COMPANY (US) | 1986-04-23 | — | — | EP | disclosed |
| US-4569801-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1986-02-11 | — | — | US | disclosed |