Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | ME2 | P23368 | 1/20 | 0.62 |
| ▸ | ME1 | P48163 | 1/20 | 0.62 |
| ▸ | ME3 | Q16798 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967794 | 0.92 | HSD11B1 (0.77) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL10722408 | 0.92 | HSD11B1 (0.77) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL5267307 | 0.87 | HSD11B1 (0.70) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL874261 | 0.85 | NPC1 (0.68) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL12519052 | 0.84 | HSD11B1 (0.76) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL6707299 | 0.84 | HSD11B1 (0.71) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL20083929 | 0.84 | HSD11B1 (0.66) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL19157381 | 0.84 | HSD11B1 (0.66) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL1492483 | 0.83 | NPC1 (0.69) | HSD11B1ALDH1A1USP2GAATSHR | |
| SCHEMBL8599235 | 0.83 | NPC1 (0.69) | HSD11B1ALDH1A1USP2GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029088-A1 | NOVEL PIPERAZINE DERIVATIVES AS TYPE IL-1 RECEPTOR ANTAGONISTS | AFFYMAX TECHNOLOGIES N.V. (AN) | 1996-09-26 | — | — | WO | disclosed |