Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.88 |
| ▸ | HTR2A | P28223 | 4/20 | 0.88 |
| ▸ | DRD3 | P35462 | 4/20 | 0.88 |
| ▸ | HTR7 | P34969 | 3/20 | 0.88 |
| ▸ | DRD4 | P21917 | 3/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.88 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.88 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.88 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.88 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.88 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.88 |
| ▸ | HRH1 | P35367 | 3/20 | 0.88 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.88 |
| ▸ | HTR2B | P41595 | 3/20 | 0.88 |
| ▸ | HTR6 | P50406 | 3/20 | 0.88 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.88 |
| ▸ | NPC1 | O15118 | 2/20 | 0.88 |
| ▸ | USP2 | O75604 | 2/20 | 0.88 |
| ▸ | LMNA | P02545 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spiperone SCHEMBL116031 | 0.94 | DRD2 (1.00) | DRD2HTR2ADRD3HTR7DRD4 | |
| Spiperone SCHEMBL466892 | 0.93 | HTR7 (1.00) | DRD2HTR2ADRD3HTR7DRD4 | |
| Spiperone SCHEMBL9213600 | 0.90 | DRD2 (0.93) | DRD2HTR2ADRD3HTR7DRD4 | |
| Fluspiperone SCHEMBL121266 | 0.89 | DRD2 (0.90) | DRD2HTR2ADRD3HTR7DRD4 | |
| Spiperone SCHEMBL4279344 | 0.89 | DRD2 (0.89) | DRD2HTR2ADRD3HTR7DRD4 | |
| SCHEMBL10735272 | 0.87 | DRD2 (0.86) | DRD2HTR2ADRD3HTR7DRD4 | |
| SCHEMBL10729769 | 0.84 | DRD2 (0.82) | DRD2HTR2ADRD3HTR7DRD4 | |
| SCHEMBL12188097 | 0.83 | DRD2 (0.80) | DRD2HTR2ADRD3HTR7DRD4 | |
| Spiperone SCHEMBL6160476 | 0.83 | HTR7 (0.81) | DRD2HTR2ADRD3HTR7DRD4 | |
| Spiperone SCHEMBL10971898 | 0.83 | DRD2 (0.76) | DRD2HTR2ADRD3HTR7DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996030054-A1 | 99mTc - LABELLED SEROTONIN RECEPTOR BINDING SUBSTANCES | MALLINCKRODT MEDICAL, INC. (US) | 1996-10-03 | — | — | WO | disclosed |