Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | FCER2 | P06734 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935308 | 1.00 | PDCD1 (0.44) | PDCD1CD274LMNAPSMB5MMP8 | |
| SCHEMBL10013375 | 0.95 | PSMB5 (0.46) | PDCD1CD274PSMB5MMP8MMP1 | |
| SCHEMBL9514815 | 0.93 | FFAR1 (0.43) | PDCD1CD274PSMB5MMP8MMP1 | |
| SCHEMBL7402132 | 0.93 | FFAR1 (0.43) | PDCD1CD274PSMB5MMP8MMP1 | |
| SCHEMBL7397778 | 0.90 | FFAR1 (0.51) | — | |
| SCHEMBL8935368 | 0.90 | FFAR1 (0.51) | — | |
| SCHEMBL7399665 | 0.86 | KCNT1 (0.49) | PDCD1CD274MMP1MMP9 | |
| SCHEMBL7402130 | 0.86 | ALDH1A1 (0.44) | PDCD1CD274LMNAPSMB5MMP8 | |
| SCHEMBL9514811 | 0.86 | ALDH1A1 (0.44) | PDCD1CD274LMNAPSMB5MMP8 | |
| SCHEMBL7397721 | 0.86 | KCNT1 (0.49) | PDCD1CD274MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502079-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-03-26 | — | — | US | disclosed |
| US-5391577-A | Active on central nervous system; antiepileptic agents | FARMITALIA CARLO ERBA S R L (IT) | 1995-02-21 | — | — | US | disclosed |
| US-5236957-A | Antiepileptic agents | FARMITALIA CARLO ERBA SRL (IT) | 1993-08-17 | — | — | US | disclosed |