Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 6/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 6/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 5/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 5/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935514 | 0.91 | CHRM2 (0.84) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL8935498 | 0.70 | CHRM2 (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL8935429 | 0.70 | CHRM2 (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL8935494 | 0.70 | CHRM2 (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL3217359 | 0.69 | CHRNA7 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL4692922 | 0.69 | CHRM2 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL9145005 | 0.68 | CHRM5 (0.51) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL8935456 | 0.68 | CHRNA7 (0.58) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL4692926 | 0.67 | CHRNA7 (0.51) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL9373682 | 0.67 | CHRM2 (0.50) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541194-A | PHARMACEUTICAL COMPOSTION USED TO TREAT DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1996-07-30 | — | — | US | claimed |
| EP-0322182-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1989-06-28 | — | — | EP | claimed |
| US-5541194-A | PHARMACEUTICAL COMPOSTION USED TO TREAT DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1996-07-30 | — | — | US | disclosed |
| EP-0322182-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1989-06-28 | — | — | EP | disclosed |