Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | RBP4 | P02753 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935731 | 1.00 | PPARG (0.54) | PPARGALDH1A1KDM4EGAARXRA | |
| SCHEMBL5861902 | 0.86 | PPARG (0.72) | PPARGRXRARXRBRXRGATM | |
| SCHEMBL28634308 | 0.83 | SMN1; SMN2 (0.46) | PPARGALDH1A1GAASMN1; SMN2PPARA | |
| SCHEMBL28331362 | 0.81 | SMN1; SMN2 (0.46) | PPARGALDH1A1KDM4EGAARXRA | |
| SCHEMBL133937 | 0.79 | PPARG (0.46) | PPARGALDH1A1KDM4EGAARXRA | |
| SCHEMBL8935641 | 0.79 | SMN1; SMN2 (0.57) | PPARGALDH1A1KDM4ERXRARXRB | |
| SCHEMBL8935961 | 0.79 | SMN1; SMN2 (0.49) | PPARGSMN1; SMN2NPSR1PPARATSHR | |
| SCHEMBL17633012 | 0.79 | SMN1; SMN2 (0.49) | PPARGGAASMN1; SMN2PPARATSHR | |
| SCHEMBL8935639 | 0.79 | KMT2A (0.62) | PPARGALDH1A1SMN1; SMN2NPSR1PPARA | |
| SCHEMBL4650644 | 0.79 | KMT2A (0.62) | PPARGALDH1A1SMN1; SMN2NPSR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |