Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.69 |
| ▸ | PPARA | Q07869 | 9/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234211 | 1.00 | PPARG (0.69) | PPARGPPARAMAPTALDH1A1GAA | |
| SCHEMBL7507747 | 0.87 | PPARG (0.66) | PPARGPPARAMAPTALDH1A1GAA | |
| SCHEMBL8935780 | 0.84 | PPARA (0.52) | PPARGPPARAMAPTSMN1; SMN2HPGD | |
| SCHEMBL8935782 | 0.84 | PPARA (0.52) | PPARGPPARAMAPTSMN1; SMN2HPGD | |
| SCHEMBL4654231 | 0.82 | PPARG (0.59) | PPARGPPARAMAPTALDH1A1GAA | |
| SCHEMBL17633012 | 0.81 | SMN1; SMN2 (0.49) | PPARGPPARAMAPTGAASMN1; SMN2 | |
| SCHEMBL8935641 | 0.81 | SMN1; SMN2 (0.57) | PPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL8935639 | 0.81 | KMT2A (0.62) | PPARGPPARAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3879629 | 0.81 | SMN1; SMN2 (0.57) | PPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL8935961 | 0.81 | SMN1; SMN2 (0.49) | PPARGPPARAMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |