Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936156 | 1.00 | MAOB (0.51) | MAOBALDH1A1TSHRSMN1; SMN2ADRA2B | |
| SCHEMBL9490336 | 0.85 | MAOB (0.53) | MAOBALDH1A1TSHRSMN1; SMN2ADRA2B | |
| SCHEMBL8936171 | 0.84 | MAOB (0.51) | MAOBALDH1A1TSHRSMN1; SMN2ADRA2B | |
| SCHEMBL8936167 | 0.84 | MAOB (0.51) | MAOBALDH1A1TSHRSMN1; SMN2ADRA2B | |
| SCHEMBL19784841 | 0.84 | MAOB (0.53) | MAOBALDH1A1TSHRSMN1; SMN2ADRA2B | |
| SCHEMBL10510837 | 0.80 | MAOB (0.48) | MAOBALDH1A1TSHRSMN1; SMN2ADRA2B | |
| SCHEMBL9816864 | 0.80 | BCHE (0.51) | ALDH1A1TSHRSMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL9816888 | 0.80 | BCHE (0.51) | ALDH1A1TSHRSMN1; SMN2ADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL9816861 | 0.78 | TSHR (0.50) | ALDH1A1TSHRSMN1; SMN2ADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL9816855 | 0.78 | TSHR (0.50) | ALDH1A1TSHRSMN1; SMN2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659178-A4 | CHIRAL QUINOLONE INTERMEDIATES. | ABBOTT LAB (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0659178-A1 | CHIRAL QUINOLONE INTERMEDIATES | ABBOTT LABORATORIES (US) | 1995-06-28 | — | — | EP | disclosed |
| WO-1994006766-A1 | CHIRAL QUINOLONE INTERMEDIATES | ABBOTT LABORATORIES (US) | 1994-03-31 | — | — | WO | disclosed |
| US-5252747-A | Chiral quinolone intermediates | ABBOTT LABORATORIES (US) | 1993-10-12 | — | — | US | disclosed |