Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6254428 | 0.74 | ERN1 (0.46) | POLBKMT2ALMNACYP1A2ALDH1A1 | |
| SCHEMBL6254422 | 0.74 | ERN1 (0.46) | POLBKMT2ALMNACYP1A2ALDH1A1 | |
| SCHEMBL8936216 | 0.72 | POLB (0.44) | POLBTHRBIDEPRNPRXFP1 | |
| SCHEMBL3709985 | 0.71 | NR4A2 (0.56) | PRNPRXFP1NR4A2SOS2KMT2A | |
| SCHEMBL8936170 | 0.71 | IDE (0.44) | POLBTHRBIDEPRNPRXFP1 | |
| SCHEMBL8662087 | 0.70 | MAOB (0.42) | POLBKMT2ACYP1A2HSD17B10MAPT | |
| SCHEMBL8662084 | 0.70 | MAOB (0.42) | POLBKMT2ACYP1A2HSD17B10MAPT | |
| SCHEMBL8367161 | 0.69 | NR4A2 (0.58) | POLBTHRBPRNPRXFP1NR4A2 | |
| SCHEMBL10377143 | 0.68 | POLB (0.63) | POLBTHRBIDEPRNPRXFP1 | |
| SCHEMBL8057207 | 0.68 | CNR1 (0.67) | NR4A2SOS2KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |