Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6254422 | 1.00 | ERN1 (0.46) | ERN1ABL1ABCB1BCRKMT2A | |
| SCHEMBL8662087 | 0.75 | MAOB (0.42) | KMT2AMEN1TDP1NR1I2POLB | |
| SCHEMBL8662084 | 0.75 | MAOB (0.42) | KMT2AMEN1TDP1NR1I2POLB | |
| SCHEMBL6254433 | 0.75 | ABL1 (0.41) | ERN1ABL1ABCB1BCRKMT2A | |
| SCHEMBL8936166 | 0.74 | POLB (0.42) | KMT2ATDP1POLBMAPTGAA | |
| SCHEMBL28283048 | 0.72 | TTR (0.58) | ERN1ABL1ABCB1BCRKMT2A | |
| SCHEMBL28283049 | 0.72 | TTR (0.58) | ERN1ABL1ABCB1BCRKMT2A | |
| SCHEMBL9121817 | 0.71 | KMT2A (0.33) | KMT2AMEN1TDP1NR1I2EGFR | |
| SCHEMBL9122474 | 0.71 | KMT2A (0.33) | KMT2AMEN1TDP1NR1I2EGFR | |
| SCHEMBL6253586 | 0.71 | POLB (0.67) | ERN1KMT2AMEN1TDP1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572704-A1 | PHOSPHORUS-CONTAINING PIPERAZINE DERIVATIVES AS CCR1 ANTAGONISTS | Pfizer Products Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040127465-A1 | Novel phosphorus-containing derivatives | PFIZER INC | 2004-07-01 | — | — | US | disclosed |
| WO-2004055031-A1 | PHOSPHORUS-CONTAINING PIPERAZINE DERIVATIVES AS CCR1 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2004-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127465-A1 | Novel phosphorus-containing derivatives | SLC34A2, SLC34A1, SLC20A1 | ERN1 1918/4885ABL1 3867/4885ABCB1 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.