Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936103 | 0.81 | TP53 (0.51) | SMN1; SMN2TP53LMNACA9PARP1 | |
| SCHEMBL6254703 | 0.75 | KMT2A (0.46) | SMN1; SMN2TP53LMNAALOX15CA9 | |
| SCHEMBL8936145 | 0.74 | TP53 (0.57) | SMN1; SMN2TP53LMNACA9PARP1 | |
| SCHEMBL8936088 | 0.72 | CA12 (0.36) | ALOX15CA9GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8936072 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2ALOX15 | |
| SCHEMBL8936216 | 0.72 | POLB (0.44) | SMN1; SMN2LMNA | |
| SCHEMBL8936133 | 0.72 | TP53 (0.54) | SMN1; SMN2TP53LMNACA9PARP1 | |
| SCHEMBL8936102 | 0.72 | GRIN2D (0.36) | SMN1; SMN2TP53LMNACA9GRIN2D | |
| SCHEMBL10912425 | 0.68 | TAAR1 (0.44) | — | |
| SCHEMBL2797754 | 0.67 | TP53 (1.00) | SMN1; SMN2TP53LMNACA9PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |