Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936191 | 0.80 | GRIN2D (0.39) | SMN1; SMN2KMT2AALDH1A1MEN1GAA | |
| SCHEMBL8936102 | 0.79 | GRIN2D (0.36) | SMN1; SMN2KMT2AALDH1A1EGFRMEN1 | |
| SCHEMBL8936178 | 0.73 | GPR17 (0.38) | SMN1; SMN2KMT2AALDH1A1MEN1GAA | |
| SCHEMBL8936172 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2ALOX15 | |
| SCHEMBL23525666 | 0.70 | CCNT1 (0.39) | EGFRL3MBTL1 | |
| SCHEMBL30791331 | 0.70 | CCNT1 (0.39) | EGFRL3MBTL1 | |
| SCHEMBL8936088 | 0.69 | CA12 (0.36) | KMT2AMEN1ALOX15HPGD | |
| SCHEMBL13264599 | 0.69 | KDM4E (0.62) | SMN1; SMN2ALDH1A1GAAKDM4EGLA | |
| SCHEMBL6298909 | 0.67 | TSHR (0.46) | KMT2AEGFRMEN1GAA | |
| SCHEMBL23908226 | 0.66 | TSHR (0.50) | KMT2AEGFRMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |