SCHEMBL8936384

SCHEMBL8936384

COc1ccc(CNC(=O)c2ccccc2)cc1.COc1ccccc1CNC(=O)c1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.69
GAA P10253 2/20 0.69
NPC1 O15118 4/20 0.68
RAB9A P51151 4/20 0.68
HTT P42858 2/20 0.68
HDAC1 Q13547 1/20 0.66
MAPT P10636 2/20 0.63
ALDH1A1 P00352 4/20 0.62
PKM P14618 1/20 0.62
RORC P51449 1/20 0.60
MEN1 O00255 2/20 0.59
KMT2A Q03164 2/20 0.59
EPHX2 P34913 1/20 0.59
NR1H4 Q96RI1 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2C9 P11712 1/20 0.58
CYP2C19 P33261 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2526264 0.89 NPC1 (0.83) HPGDGAANPC1RAB9AHDAC1
SCHEMBL6848785 0.89 HTT (0.83) HPGDGAANPC1RAB9AHTT
SCHEMBL3306757 0.84 HTT (0.76) HPGDGAAHTTHDAC1MAPT
SCHEMBL2918147 0.83 NPC1 (0.83) HPGDGAANPC1RAB9AALDH1A1
SCHEMBL8759043 0.83 HPGD (0.70) HPGDGAAHTTHDAC1MAPT
SCHEMBL15911480 0.83 HPGD (0.70) HPGDGAAHTTHDAC1MAPT
SCHEMBL9416606 0.82 NPC1 (0.82) HPGDGAANPC1RAB9AHDAC1
SCHEMBL11761142 0.82 NPC1 (0.82) HPGDGAANPC1RAB9AHDAC1
SCHEMBL1926263 0.81 NPC1 (1.00) HPGDGAANPC1RAB9AHTT
SCHEMBL5331526 0.81 MMP13 (0.74) HPGDNPC1RAB9AHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5580751-A REACTING A PEPTIDE WITH A NUCLEOPHILIC AMINE IN THE PRESENCE OF TRYPSIN OR A CARBOXYPEPIDASE; NONENZYMATICALLY CLEAVING TO FORM THE PRODUCT CARLSBERG A/S (DK) 1996-12-03 US disclosed