Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.83 |
| ▸ | RAB9A | P51151 | 4/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.71 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2918147 | 0.94 | NPC1 (0.83) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL9416606 | 0.92 | NPC1 (0.82) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL11761142 | 0.92 | NPC1 (0.82) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL5331526 | 0.91 | MMP13 (0.74) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL1926263 | 0.91 | NPC1 (1.00) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL26101164 | 0.89 | NPC1 (0.80) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL8936384 | 0.89 | HPGD (0.69) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL5331977 | 0.89 | MMP13 (0.76) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL1926645 | 0.87 | NPC1 (0.78) | NPC1RAB9AEPHX2NR1H4ALDH1A1 | |
| SCHEMBL20804653 | 0.87 | NPC1 (0.70) | NPC1RAB9AKMT2AMEN1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4249551-A | — | — | None | — | — | JP | disclosed |
| CN-118005468-B | Method for synthesizing N-alkylated amide compound by catalyzing alcohols and nitriles with nitrogen-carbon material | 常州大学 | 2026-05-19 | — | — | CN | disclosed |
| US-12018012-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| CN-118005468-A | Method for synthesizing N-alkylated amide compound by catalyzing alcohols and nitriles with nitrogen-carbon material | 常州大学 | 2024-05-10 | — | — | CN | disclosed |
| US-20230130470-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | ALCON INC. (CH) | 2023-04-27 | — | — | US | disclosed |
| US-11312700-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2022-04-26 | — | — | US | disclosed |
| CN-114292247-A | Disulfide compound and method for catalyzing benzyl oxidation of alkyl aromatic compound by using disulfide compound | 大连理工大学 | 2022-04-08 | — | — | CN | disclosed |
| CN-109824465-B | Method for synthesizing amide by amine oxide catalyzed by bipyridine manganese catalyst | 陕西师范大学 | 2022-01-04 | — | — | CN | disclosed |
| US-20210002253-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | ALCON INC. (CH) | 2021-01-07 | — | — | US | disclosed |
| WO-2019174279-A1 | 1,2-BENZISOSELENAZOL-3(2H)-ONE AND 1,2-BENZISOTHIAZOL-3(2H)-ONE DERIVATIVES AS BETA-LACTAM ANTIBIOTIC ADJUVANTS | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2019-09-19 | — | — | WO | disclosed |
| EP-2480530-A1 | ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| US-8039669-B2 | Catalytic metathesis of secondary amides | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2011033099-A1 | ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |
| US-20090299098-A1 | Catalytic Metathesis of Secondary Amides | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-12-03 | — | — | US | disclosed |
| EP-0548217-B1 | PROCESS FOR THE PREPARATION OF C-TERMINALLY AMIDATED PEPTIDES | BUCHARDT OLE (DK) | 1997-04-09 | — | — | EP | disclosed |
| US-5580751-A | REACTING A PEPTIDE WITH A NUCLEOPHILIC AMINE IN THE PRESENCE OF TRYPSIN OR A CARBOXYPEPIDASE; NONENZYMATICALLY CLEAVING TO FORM THE PRODUCT | CARLSBERG A/S (DK) | 1996-12-03 | — | — | US | disclosed |
| EP-0548217-A1 | PROCESS FOR THE PREPARATION OF C-TERMINALLY AMIDATED PEPTIDES. | BUCHARDT OLE (DK) | 1993-06-30 | — | — | EP | disclosed |
| JP-H04249551-A | RUBBER COMPOSITION | SUMITOMO CHEM CO LTD | 1992-09-04 | — | — | JP | disclosed |
| WO-1992005271-A1 | PROCESS FOR THE PREPARATION OF C-TERMINALLY AMIDATED PEPTIDES | BUCHARDT OLE (DK) | 1992-04-02 | — | — | WO | disclosed |
| EP-0300526-A2 | Antiviral pharmaceutical compositions containing cyclodextrins | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002253-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | UACA, HRAS, MYLK | NPC1 2104/4885RAB9A 541/4885KMT2A 1750/4885 |
| US-20090299098-A1 | Catalytic Metathesis of Secondary Amides | NAAA, NAT1, NAT10 | NPC1 2288/4885RAB9A 510/4885KMT2A 760/4885 |
| US-12018012-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | UACA, HRAS, MYLK | NPC1 2104/4885RAB9A 541/4885KMT2A 1750/4885 |
| US-11312700-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | UACA, HRAS, MYLK | NPC1 2104/4885RAB9A 541/4885KMT2A 1750/4885 |
| US-20230130470-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | UACA, HRAS, MYLK | NPC1 2104/4885RAB9A 541/4885KMT2A 1750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.