Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9334794 | 0.88 | TSHR (0.41) | KDM4EALDH1A1TP53GAA | |
| SCHEMBL9334812 | 0.88 | GABRA1 (0.48) | KMT2AKDM4EMAPTNPSR1PTGDR2 | |
| SCHEMBL9334779 | 0.87 | TSHR (0.40) | KMT2AKDM4EMAPTNPSR1SERPINE1 | |
| SCHEMBL9338390 | 0.86 | GAA (0.44) | HSP90AA1KMT2APTGDR2ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL9338296 | 0.85 | TSHR (0.49) | KMT2AKDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL9338270 | 0.85 | KCNK3 (0.48) | KDM4EMAPTPTGDR2ALDH1A1TP53 | |
| SCHEMBL9336250 | 0.85 | KDM4E (0.40) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL9335866 | 0.85 | ALDH1A1 (0.39) | KDM4EMAPTALDH1A1TP53GAA | |
| SCHEMBL9338503 | 0.85 | KDM4E (0.49) | KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL9334715 | 0.85 | HCRTR1 (0.39) | TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | claimed |
| JP-7188229-A | — | — | None | — | — | JP | disclosed |
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5561233-A | Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5561233-A | Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| JP-H07188229-A | PREPARATION OF BENZO(A)QUINOLIZINONE DERIVATIVE | F HOFFMANN LA ROCHE AG | 1995-07-25 | — | — | JP | disclosed |
| US-5326769-A | Treatment of sleep disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5321021-A | Tricyclic pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-06-14 | — | — | US | disclosed |
| US-5281711-A | (S)-1-[10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quino-lizin-1-yl)carbonyl]-3-ethoxypyrrolidine | HOFFMANN-LA ROCHE INC. (US) | 1994-01-25 | — | — | US | disclosed |
| CN-1016871-B | Process for the preparation of bicyclic and tricyclic pyridine derivatives | HOFFMANN LA ROCHE 7 CO F (CN) | 1992-06-03 | — | — | CN | disclosed |
| US-5036066-A | Muscle relaxants, anxiolytic agents, anticonvulsants | HOFFMANN-LA ROCHE INC. (US) | 1991-07-30 | — | — | US | disclosed |
| US-4889848-A | 4-OXO-4H-BENZO(A)QUINOLIZINES; MUSCLE RELAXANTS; SEDATIVES; ANTICONVULSANTS; ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4735940-A | Tricyclic pyridine derivatives and pharmaceutical compositions | HOFFMANN-LA ROCHE INC. (US) | 1988-04-05 | — | — | US | disclosed |
| CN-85108120-A | The preparation of tricyclic pyridine derivative and application thereof | — | 1986-11-05 | — | — | CN | disclosed |