Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202210 | 0.81 | BRD4 (0.51) | BRD4CYP19A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9198430 | 0.81 | BRD4 (0.46) | BRD4CYP19A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8936696 | 0.78 | BRD4 (0.51) | BRD4CYP19A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8936736 | 0.78 | CYP19A1 (0.53) | BRD4CYP19A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9202769 | 0.78 | BRD4 (0.51) | BRD4CYP19A1HDAC1HDAC6 | |
| SCHEMBL9197402 | 0.74 | CYP19A1 (0.56) | BRD4CYP19A1KMT2A | |
| SCHEMBL8507241 | 0.74 | CYP19A1 (0.60) | CYP19A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8936807 | 0.73 | CYP19A1 (0.58) | BRD4CYP19A1CYP2C19KDM4EHSP90AA1 | |
| SCHEMBL14476866 | 0.72 | CYP19A1 (0.56) | CYP19A1HDAC1HDAC6UGT1A4PDE4D | |
| SCHEMBL9826863 | 0.70 | HSP90AA1 (0.54) | CYP19A1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587392-A | THERAPY FOR ESTROGEN DEPENDENT DISEASES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0684235-A1 | Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-29 | — | — | EP | disclosed |