Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acetylcysteine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.62 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | GSR | P00390 | 1/20 | 0.59 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 5/20 | 0.43 |
| ▸ | NOS1 | P29475 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcysteine SCHEMBL663169 | 1.00 | BLM (0.62) | BLMKDM4EMAPTTHRBALOX15 | |
| Acetylcysteine SCHEMBL663170 | 1.00 | BLM (0.62) | BLMKDM4EMAPTTHRBALOX15 | |
| Acetylcysteine SCHEMBL27772811 | 0.95 | KDM4E (0.64) | BLMKDM4EMAPTTHRBALOX15 | |
| Lysine SCHEMBL18006519 | 0.89 | GSR (0.65) | BLMKDM4EMAPTTHRBALOX15 | |
| Lysine SCHEMBL18006518 | 0.89 | GSR (0.65) | BLMKDM4EMAPTTHRBALOX15 | |
| Acetylcysteine SCHEMBL9016357 | 0.84 | ALOX15 (0.70) | BLMKDM4EMAPTTHRBALOX15 | |
| Acetylcysteine SCHEMBL28342967 | 0.84 | ALOX15 (0.70) | BLMKDM4EMAPTTHRBALOX15 | |
| Acetylglutamic Acid SCHEMBL11756644 | 0.84 | FOLH1 (0.64) | GSRSIRT6SIRT1FOLH1CYP1A2 | |
| SCHEMBL21828643 | 0.83 | GSR (0.55) | BLMKDM4EMAPTTHRBALOX15 | |
| SCHEMBL14957758 | 0.83 | GSR (0.55) | BLMKDM4EMAPTTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4169380-A1 | AGRICULTURAL COMPOSITION FOR THE TREATMENT AND PREVENTION OF BACTERIAL DISEASES AND DISORDERS | Amazon Agrosciences Ltda (BR) | 2023-04-26 | — | — | EP | claimed |
| US-20210392886-A1 | Agricultural Composition for the Treatment and Prevention of Bacterial Diseases and Disorders | Instituto Agronômico (IAC) (BR) | 2021-12-23 | — | — | US | claimed |
| EP-2976061-B1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | DENTALMED PHARM HOLDING LTD (BE) | 2019-10-16 | — | — | EP | claimed |
| US-20160279043-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | DENTALMED PHARM HOLDING LTD. (BE) | 2016-09-29 | — | — | US | claimed |
| EP-2976061-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | Dentalmed Pharm Holding Ltd. (BE) | 2016-01-27 | — | — | EP | claimed |
| WO-2014147613-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | DENTALMED PHARM HOLDING LTD. (BE) | 2014-09-25 | — | — | WO | claimed |
| US-20140024857-A1 | CYSTEINE AMINO-ACID COMPOUND (OR ITS ANALOGUES) USED IN THE DISRUPTION OF MICROBIAL BIOFILMS WHEN TREATING OR PREVENTING DISEASES CAUSED BY PHYTOPATHOGENIC BACTERIA KNOWN TO ATTACK PLANTS OF AGRICULTURAL INTEREST | INSTITUTO AGRONOMICO DE CAMPINAS - IAC (BR) | 2014-01-23 | — | — | US | claimed |
| CN-102316730-A | Controlled release of N-acetylcysteine (NAC) for reduction of systemic and/or vascular inflammation | TIARA PHARMACEUTICALS INC | 2012-01-11 | — | — | CN | claimed |
| CN-101664384-B | N-acetyl-cysteine salt xylitol injection, preparation method and application thereof | SIXTH PEOPLE S HOSPITAL OF HANGZHOU | 2011-09-14 | — | — | CN | claimed |
| CN-1874757-B | Mucoactive agents for treating a pulmonary disease | VECTURA LTD | 2011-03-09 | — | — | CN | claimed |
| CN-101664384-A | N-acetyl-cysteine salt xylitol injection, preparation method and application thereof | SIXTH PEOPLE S HOSPITAL OF HAN | 2010-03-10 | — | — | CN | claimed |
| EP-0964675-A1 | DRY POWDER INHALER EXCIPIENT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | "PHARLYSE", Société Anonyme (LU) | 1999-12-22 | — | — | EP | claimed |
| WO-1998050015-A1 | DRY POWDER INHALER EXCIPIENT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | PHARLYSE, SOCIETE ANONYME (LU) | 1998-11-12 | — | — | WO | claimed |
| EP-4333853-A1 | METHODS FOR TREATING A PULMONARY DISEASE WITH AN ALK-5 (TGF BETA R1) INHIBITOR | Thirona Bio, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-117615765-A | Methods of treating pulmonary diseases with ALK-5 (TGF beta R1) inhibitors | 蒂罗纳生物股份有限公司 | 2024-02-27 | — | — | CN | disclosed |
| US-20230130132-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AMPHIPHILIC PEPTIDES AND METHODS OF USE THEREOF | BONE SCI. BIO LTD. (IL) | 2023-04-27 | — | — | US | disclosed |
| CN-1874757-A | Mucoactive agents for treating a pulmonary disease | VECTURA LTD (GB) | 2006-12-06 | — | — | CN | disclosed |
| EP-0964675-A1 | DRY POWDER INHALER EXCIPIENT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | "PHARLYSE", Société Anonyme (LU) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998050015-A1 | DRY POWDER INHALER EXCIPIENT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | PHARLYSE, SOCIETE ANONYME (LU) | 1998-11-12 | — | — | WO | disclosed |
| US-4847282-A | Mucolytic acetylcysteine salts | GALEPHAR (BE) | 1989-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279043-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | SIRT3, NNT, SIRT1 | PTGS2 208/4885PTGS1 185/4885BLM 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.