Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Mandelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mandelic Acid SCHEMBL3711577 | 0.85 | LMNA (0.69) | LMNAMAPK1SMN1; SMN2FFAR1CYP2D6 | |
| Mandelic Acid SCHEMBL3456058 | 0.81 | LMNA (0.62) | LMNAMAPK1SMN1; SMN2CYP2D6CYP2C19 | |
| Cadaverine Tartrate SCHEMBL8157715 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2FFAR1TSHRMEN1KMT2A | |
| Cadaverine Tartrate SCHEMBL8157703 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2FFAR1TSHRMEN1KMT2A | |
| Mandelic Acid SCHEMBL8630179 | 0.78 | LMNA (0.82) | LMNAMAPK1TP53CYP1A2CYP2D6 | |
| Cadaverine Tartrate SCHEMBL18895372 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2TP53TSHR | |
| Mandelic Acid SCHEMBL531056 | 0.76 | LMNA (0.86) | LMNAMAPK1CYP2D6TSHRHPGD | |
| Malic Acid SCHEMBL339198 | 0.76 | TAAR1 (0.63) | LMNAMAPK1SMN1; SMN2FFAR1CYP2C19 | |
| Malic Acid SCHEMBL6787423 | 0.76 | TAAR1 (0.63) | LMNAMAPK1SMN1; SMN2FFAR1CYP2C19 | |
| Malic Acid SCHEMBL7191878 | 0.76 | TAAR1 (0.63) | LMNAMAPK1SMN1; SMN2FFAR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668808-A4 | NO-CLEAN SOLDERING FLUX AND METHOD USING THE SAME. | FRY METALS INC (US) | 1996-04-24 | — | — | EP | disclosed |
| EP-0668808-A1 | NO-CLEAN SOLDERING FLUX AND METHOD USING THE SAME | FRY'S METALS, INC. (US) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994011148-A1 | NO-CLEAN SOLDERING FLUX AND METHOD USING THE SAME | FRY'S METALS, INC. (US) | 1994-05-26 | — | — | WO | disclosed |