Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937298 | 1.00 | KMT2A (0.56) | KMT2AMEN1MTNR1AMTNR1BNPC1 | |
| SCHEMBL8937295 | 1.00 | KMT2A (0.56) | KMT2AMEN1MTNR1AMTNR1BNPC1 | |
| SCHEMBL8937427 | 0.85 | KMT2A (0.64) | KMT2AMEN1NPC1RAB9ACES2 | |
| SCHEMBL8937417 | 0.85 | KMT2A (0.64) | KMT2AMEN1NPC1RAB9ACES2 | |
| SCHEMBL8937423 | 0.85 | KMT2A (0.64) | KMT2AMEN1NPC1RAB9ACES2 | |
| SCHEMBL9396296 | 0.84 | CES2 (0.62) | KMT2AMEN1MTNR1AMTNR1BNPC1 | |
| SCHEMBL8937425 | 0.82 | NPC1 (0.56) | KMT2AMEN1MTNR1AMTNR1BNPC1 | |
| SCHEMBL8937419 | 0.82 | NPC1 (0.56) | KMT2AMEN1MTNR1AMTNR1BNPC1 | |
| SCHEMBL8937430 | 0.82 | NPC1 (0.56) | KMT2AMEN1MTNR1AMTNR1BNPC1 | |
| SCHEMBL7218671 | 0.81 | ALDH1A1 (0.53) | NPC1RAB9ACES2CES1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |