Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | RORB | Q92753 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937318 | 1.00 | LMNA (0.47) | LMNAGRM5CA12CA1CA2 | |
| SCHEMBL23393319 | 0.85 | RAB9A (0.55) | LMNACA12CA1CA2CA9 | |
| SCHEMBL21486409 | 0.85 | RAB9A (0.55) | LMNACA12CA1CA2CA9 | |
| SCHEMBL8999190 | 0.79 | GRM5 (0.48) | LMNAGRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8937376 | 0.76 | LMNA (0.48) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8937382 | 0.76 | LMNA (0.48) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8937521 | 0.76 | LMNA (0.48) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7823036 | 0.76 | CA12 (0.54) | LMNACA12CA1CA2CA9 | |
| SCHEMBL8937361 | 0.75 | HPGD (0.50) | CA1CA2RAB9AMAPTKDM4E | |
| SCHEMBL8937315 | 0.75 | HPGD (0.50) | CA1CA2RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |