Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | TNKS | O95271 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31320929 | 1.00 | HSD17B3 (0.76) | HSD17B3NPSR1HDAC3TNKSHDAC4 | |
| SCHEMBL236624 | 1.00 | HSD17B3 (0.76) | HSD17B3NPSR1HDAC3TNKSHDAC4 | |
| SCHEMBL236623 | 1.00 | HSD17B3 (0.76) | HSD17B3NPSR1HDAC3TNKSHDAC4 | |
| SCHEMBL11470768 | 0.98 | HSD17B3 (0.73) | HSD17B3NPSR1HDAC3TNKSHDAC4 | |
| Hydrochloric Acid SCHEMBL6818198 | 0.98 | HSD17B3 (0.73) | HSD17B3NPSR1HDAC3TNKSHDAC4 | |
| SCHEMBL1035544 | 0.86 | HSD17B3 (0.79) | HSD17B3NPSR1SLC6A19BACE1CYP2D6 | |
| SCHEMBL1035543 | 0.86 | HSD17B3 (0.79) | HSD17B3NPSR1SLC6A19BACE1CYP2D6 | |
| SCHEMBL271386 | 0.86 | NPSR1 (0.74) | HSD17B3NPSR1HDAC3TNKSHDAC4 | |
| SCHEMBL69146 | 0.86 | NPSR1 (0.74) | HSD17B3NPSR1HDAC3TNKSHDAC4 | |
| SCHEMBL29162914 | 0.85 | HSD17B3 (0.71) | HSD17B3NPSR1SLC6A19BACE1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |