Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.37 |
| ▸ | PRKACA | P17612 | 4/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.35 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 3/20 | 0.35 |
| ▸ | PRKACB | P22694 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8934889 | 0.84 | ROCK1 (0.53) | ROCK1MAP2K1PRKACAROCK2PRKCD | |
| SCHEMBL8937945 | 0.84 | ROCK1 (0.56) | ROCK1MAP2K1PRKACAROCK2PRKACG | |
| SCHEMBL8937942 | 0.83 | ROCK1 (0.55) | ROCK1MAP2K1ACHE | |
| SCHEMBL8937839 | 0.82 | ROCK1 (0.52) | ROCK1SCN8AACHE | |
| SCHEMBL12165509 | 0.81 | ROCK1 (0.48) | ROCK1MAP2K1S1PR5PRKACAROCK2 | |
| SCHEMBL8937944 | 0.81 | ROCK1 (0.52) | ROCK1PRKACAPRKACGPRKACBSCN1A | |
| SCHEMBL8937951 | 0.81 | ROCK1 (0.52) | ROCK1MAP2K1SCN1ASCN8AACHE | |
| SCHEMBL8938080 | 0.81 | ROCK1 (0.61) | ROCK1MAP2K1PRKACAROCK2PRKCD | |
| SCHEMBL8937933 | 0.81 | ROCK1 (0.54) | ROCK1MAP2K1PRKACAPRKACGPRKACB | |
| SCHEMBL8937943 | 0.80 | ROCK1 (0.56) | ROCK1MAP2K1PRKACAROCK2PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385047-B1 | Piperidinyl-substituted isoquinolone derivatives | SANOFI SA (FR) | 2013-05-29 | — | — | EP | disclosed |
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2009-04-09 | — | — | US | disclosed |
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | MYLK2, MYLK, RHOT2 | ROCK1 8/4885MAP2K1 1916/4885S1PR5 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.